Searchable abstracts of presentations at key conferences in endocrinology

ea0025p159 | Diabetes, metabolism and cardiovascular | SFEBES2011

Investigating the effects of testosterone on inflammatory markers of early aortic atherosclerosis in the testicular feminised mouse (Tfm) model

Kelly Daniel , Sellers Donna , Woodroofe Nicola , Jones Hugh , Channer Kevin

Objectives: The over-recruitment and activation of leukocytes characteristic of early atherosclerosis is considered the driving force behind atheroma development and is regulated by the concerted activities of several cytokines, chemokines and adhesion molecules surrounding a lipid core. Low serum testosterone levels are associated with cardiovascular disease in men and clinical trials demonstrate that testosterone replacement therapy (TRT) improves symptoms and reduces the in...